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Phage therapy: From biological mechanisms to future directions

1 Jan 2023

Abstract excerpt

Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders....

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PMID: 36608652
DOI: 10.1016/j.cell.2022.11.017

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