Back to search

Article

Targeted Alpha Therapy with [ <sup>225</sup> Ac]Ac-Macropa-Isatuximab for CD38-positive Hematological Malignancies

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hematological malignancies include diverse cancers related to immune system cells and blood-forming tissue. Treatment resistance and relapse are common despite the introduction of novel therapeutics. Following the development of the PET probe [ 89 Zr]Zr-DFO-isatuximab, targeting the overexpressed CD38 receptor, we developed [ 225 Ac]Ac-Macropa-isatuximab for targeted alpha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5dff7000-5d28-5aa6-945c-6772d0f8c137
DOI
10.1101/2024.11.01.621584
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeted Alpha Therapy with [ <sup>225</sup> Ac]Ac-Macropa-Isatuximab for CD38-positive Hematological MalignanciesDOI 10.1101/2024.11.01.621584
Targeting CD38 with Daratumumab Monotherapy in Multiple MyelomaSemantic proximity
Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood CancersSemantic proximity
T-cell engager bispecific antibodies enable T cells to eliminate Multiple Myeloma by targeting tumor CD38 in combination with PD-L1Semantic proximity
Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity.Semantic proximity
Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-β2Semantic proximity
Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivoSemantic proximity
CD46 targeted <sup>212</sup> Pb alpha particle radioimmunotherapy for prostate cancer treatmentSemantic proximity
The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapySemantic proximity
Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2Semantic proximity
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumabSemantic proximity
Dosimetry-Driven Alpha Emitter Selection for Radioligand Therapy: Is daughter translocation a significant safety concern?Semantic proximity
An Anti-EGFR Antibody-Drug Radioconjugate Labeled with Actinium-225 Elicits Durable Antitumor Responses in KRAS- and BRAF-Mutant Colorectal Cancer.Semantic proximity
Select a neighboring publication to make it the new centre.