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Article

A lung targeted miR-29 Mimic as a Therapy for Pulmonary Fibrosis

2021-12-22

Abstract excerpt

microRNAs are non-coding RNAs that negatively regulate gene networks. Previously, we reported a systemically delivered miR-29 mimic MRG-201 that reduced fibrosis in animal models, but at doses prohibiting clinical translation. Here, we generated MRG-229, a next-gen miR-29 mimic with improved chemical stability, conjugated with the internalization moiety BiPPB (PDGFbetaR-specific bicyclic peptide). In TGF-b-treated...

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Literature Corpus work
5dad8d92-0d83-55a6-b95d-f66e1ec88eb5
DOI
10.1101/2021.12.22.473724
Open publication

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A lung targeted miR-29 Mimic as a Therapy for Pulmonary FibrosisDOI 10.1101/2021.12.22.473724
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