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Article

The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.

Disease models & mechanisms - 1 Nov 2011

Melville David B, Montero-Balaguer Mercedes, Levic Daniel S, Bradley Kevin, Smith Jeffrey R, Hatzopoulos Antonis K, Knapik Ela W

Abstract excerpt

Craniofacial and skeletal dysmorphologies account for the majority of birth defects. A number of the disease phenotypes have been attributed to abnormal synthesis, maintenance and composition of extracellular matrix (ECM), yet the molecular and cellular mechanisms causing these ECM defects remain poorly understood. The zebrafish feelgood mutant manifests a severely malformed head skeleton and shortened body...

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Identifiers

PMID: 21729877
DOI: 10.1242/dmm.007625
PMCID: PMC3209646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.PMID 21729877Read ↗

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