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A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

2025-05-10

Abstract excerpt

Increased resistance to β-lactams/β-lactamase inhibitor by mutations in β-lactamases gene, porin mutations and efflux pumps complicates the management of carbapenem-resistant Klebsiella pneumoniae (CRKP). Polymyxin B (PMB) based combination therapy is considered as a best alternative treatment for those middle and low-income countries that cannot access to the latest medicines. It’s crucial to know both phenotypi...

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Literature Corpus work
5be21446-9f86-57d6-9827-5e6dc9d5fae2
DOI
10.1101/2025.05.06.652358
Open publication

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A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates with Diverse Phenotypic and Genotypic Resistance MechanismsDOI 10.1101/2025.05.06.652358
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