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Transcriptional activation and coactivator binding by yeast Ino2 and its human ortholog proto-oncoprotein c-Myc

2024-11-05

Abstract excerpt

<title>Abstract</title> <p>Basic helix-loop-helix domains in yeast regulatory proteins Ino2 and Ino4 mediate formation of a heterodimer which binds to and activates expression of phospholipid biosynthetic genes. The human proto-oncoprotein c-Myc (Myc) and its binding partner Max activate genes important for cellular proliferation and contain functional domains structure and position of which strongly resembles In...

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Literature Corpus work
5b52936a-eec3-5cbb-979b-4961f0ec4b6d
DOI
10.21203/rs.3.rs-5289560/v1
Open publication

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Transcriptional activation and coactivator binding by yeast Ino2 and its human ortholog proto-oncoprotein c-MycDOI 10.21203/rs.3.rs-5289560/v1
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