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Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non-small-cell lung cancer

2022-12-21

Abstract excerpt

<title>Abstract</title> <p>The clinical responses to the EGFR kinase inhibitors in non-small cell lung cancer (NSCLC) patients are always followed by drug-resistance mutations, including the gatekeeper T790M mutation. Strategies targeting EGFRT790M are also limited by the toxicity due to the concurrent inhibition of wide-type (WT) EGFR. Here we employed splicing principle to design and synthesize a series of amin...

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Literature Corpus work
5b23ef94-9576-5f69-a4e1-6fadab7ec080
DOI
10.21203/rs.3.rs-2356867/v1
Open publication

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Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non-small-cell lung cancerDOI 10.21203/rs.3.rs-2356867/v1
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