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Article

Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors.

European journal of medicinal chemistry - 5 Dec 2024

Dou Dou, Zhang Xingsen, Wang Jie, Wumaier Gulinuer, Qiao Yunjin, Xie Lijuan, Jiang Wenzhe, Sha Wenjie, Li Wenjie, Mei Wenyi, Zhang Chen, He Huan, Wang Caolin, Wu Lingkang, Diao Yanyan, Zhu Lili, Zhao Zhenjiang, Chen Zhuo, Xu Yufang, Li Shengqing, Li Honglin

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a validated target for non-small-cell lung cancer (NSCLC). However, the treatment for EGFR-C797S mutation induced by third-generation EGFR inhibitors remains a concern. Therefore, the development of the fourth-generation EGFR inhibitors to overcome the EGFR-C797S mutation has great potential for clinical treatment. In this article, we designed and synthesized a series of...

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PMID: 39278125
DOI: 10.1016/j.ejmech.2024.116858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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