Article
Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
Chemical & pharmaceutical bulletin - 1 Jan 2020
Zhang Mingguang, Wang Yunyun, Wang Jia, Liu Zhaogang, Shi Jingmiao, Li Mingxin, Zhu Yongqiang, Wang Shifa
Abstract excerpt
Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one of the most promising strategies for the treatment of non-small cell lung cancers. A series of 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with the purpose to overcome L858R/T790M/C797S (CTL) triple mutant drug resistance and the biological activity for inhibition of CTL kinases and EGFR wild...
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