Article

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

2023-07-19

Abstract excerpt

Trabid/ZRANB1 missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood. We have characterised these patient mutations in cells and mice to identify a key role for Trabid in the regulation of neurite growth. One of the patient mutations flanked the catalytic cysteine of Trabid and its...

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Literature Corpus work: 5b234d72-48fa-5743-8554-ff0fa9359348
DOI: 10.1101/2023.07.17.549243

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