Article

Heterogeneous Genotype-Phenotype Associations in TRIO-Related Neurodevelopmental Disorder Revealed by Meta-Analysis

2025-10-21

Abstract excerpt

<h4>Background</h4> The trio Rho guanine nucleotide exchange factor gene (TRIO) is highly expressed in the developing brain and contributes to neuronal development, specifically axon guidance, synaptogenesis, and cytoskeleton organization. Pathogenic TRIO variants are associated with a neurodevelopmental disorder with substantial phenotypic heterogeneity. Prior case series suggested genotype-phenotype associati...

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Literature Corpus work: 1058678b-a416-5c2e-bd07-577243f0590c
DOI: 10.1101/2025.10.17.25338222

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