Article

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

2020-02-24

Abstract excerpt

Cutaneous leishmaniasis (CL) is a chronic skin disease caused by Leishmania parasites and in Sri Lanka, CL is caused by L. donovani. Pentavalent antimonials (e.g. sodium stibogluconate; SSG) are first line drugs for CL, despite protracted and painful treatment regimens. Data from animal models indicate that the effectiveness of SSG requires drug-immune synergy, but mechanistic insight from patients is lacking. W...

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Literature Corpus work: 5a6d77e3-de72-58ae-b692-3f0e00a3b133
DOI: 10.1101/2020.02.21.959528

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