Salvage dacomitinib plus intraventricular pemetrexed for leptomeningeal metastasis after failure of third‑generation EGFR‑TKIs in EGFR‑mutant NSCLC: an ambispective cohort study.

Abstract excerpt

BACKGROUND: In patients with EGFR-mutant non–small cell lung cancer (NSCLC), leptomeningeal metastasis (LM) following progression on third-generation EGFR tyrosine kinase inhibitors (TKIs) remains a life-threatening complication. METHODS: In this ambispective cohort study, we included 21 patients with LM who progressed after third-generation EGFR-TKI therapy and subsequently received salvage treatment with...

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