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Article

Activin-Like Kinase 2 Functions in Peri-implantation Uterine Signaling in Mice and Humans

14 Nov 2013

Abstract excerpt

Implantation of a blastocyst in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the uterus of pregnant mice, and BMP2 has been shown to be a key regulator of implantation. In this study, we investigated the roles of the BMP type 1 receptor,...

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PMID: 24244176
DOI: 10.1371/journal.pgen.1003863

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