Article

Using genetics to uncouple higher adiposity from its adverse metabolic effects and understand its role in metabolic and non-metabolic disease.

2021-07-22

Abstract excerpt

<title>Abstract</title> <p>To understand the consequences of higher adiposity uncoupled from its adverse metabolic effects, we selected 37 diseases associated with obesity and genetic variants associated with different aspects of excess weight including metabolically “favourable adiposity” (FA) and “unfavourable adiposity” (UFA). Mendelian randomisation (MR) identified two sets of diseases. First, 12 conditions w...

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Literature Corpus work: 59b84d74-7312-5f75-af14-10976ac12fa3
DOI: 10.21203/rs.3.rs-537397/v2

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