Article

Pathogen effector forms a hexameric phosphatase holoenzyme with host core enzyme to promote disease

2025-06-18

Abstract excerpt

Pathogen effectors play critical roles in pathogenesis by directly manipulating host cellular processes. The Ser/Thr protein phosphatase 2A (PP2A) is commonly targeted by pathogens. Effectors from devastating plant pathogen Phytophthora hijack the PP2A core enzyme in plant hosts, altering the host phosphoproteome. In this study, we present a series of cryo-electron microscopy structures of the Phytophthora effec...

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Literature Corpus work: 595972b2-7be7-551f-bc06-5d95d12b615b
DOI: 10.1101/2025.06.14.659724

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Pathogen effector forms a hexameric phosphatase holoenzyme with host core enzyme to promote diseaseDOI 10.1101/2025.06.14.659724Read

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