Article
Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates.
Science signaling - 3 Apr 2018
Labandera Anne-Marie, Uhrig R Glen, Colville Keaton, Moorhead Greg B, Ng Kenneth K S
Abstract excerpt
Despite belonging to the phosphoserine- and phosphothreonine-specific phosphoprotein phosphatase (PPP) family, Arabidopsis thaliana Rhizobiales-like phosphatase 2 (RLPH2) strongly prefers substrates bearing phosphorylated tyrosine residues. We solved the structures of RLPH2 crystallized in the presence or absence of sodium tungstate. These structures revealed the presence of a central domain that forms a binding...
Topics
Join the communities discussing this publication.