Back to search

Article

Let-7a/cMyc/CCAT-1/miR-17-5p Circuit Modulates PDL-1 Expression and Atezolizumab Resistance in Triple Negative Breast Cancer

2023-01-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Triple negative breast cancer (TNBC) is an immunogenically hot tumor. The immune checkpoint blockades (ICBs) have been recently emerged as promising therapeutic candidates for several malignancies including TNBC. Yet, the development of innate and/or adaptive resistance by TNBC patients towards ICBs such as programmed death-ligand 1 (PD-L1) inhibitors (e.g. Atezo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
575e1abf-a74c-5814-b79a-c3394ca2f9f0
DOI
10.21203/rs.3.rs-2388191/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Let-7a/cMyc/CCAT-1/miR-17-5p Circuit Modulates PDL-1 Expression and Atezolizumab Resistance in Triple Negative Breast CancerDOI 10.21203/rs.3.rs-2388191/v1
PD-1/PD-L1 Inhibitors Response in Triple-Negative Breast Cancer: Can Long Noncoding RNAs Be Associated?Semantic proximity
Molecular and Clinical Characterization of PD-1 in Breast Cancer Using Large-Scale Transcriptome DataSemantic proximity
MCT4 Upregulates PD-L1 Expression and Defines Novel Composite Therapeutic Targets for Triple-Negative Breast CancerSemantic proximity
A Novel Immune-Related LncRNA Pair Model to Predict the Prognosis of Triple-Negative Breast CancerSemantic proximity
A novel lncRNA AC112721.1 promotes the progress of triple-negative breast cancer by directly binding to THBS1 and regulating the miR-491-5p/C2CD2L axisSemantic proximity
Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab.Semantic proximity
Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancerSemantic proximity
Upregulated CCNE1 Correlates with Poor Prognosis, Tumor Immune Infiltration and Escape in Breast CancerSemantic proximity
CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/β-catenin pathway.Semantic proximity
Transcriptomic insights into the development and therapy of breast cancer via the ncRNA-mediated ceRNA regulation networkSemantic proximity
Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysisSemantic proximity
Expression of long non‐coding RNA ENSG 00000226738 (Lnc KLHDC 7B) is enriched in the immunomodulatory triple‐negative breast cancer subtype and its alteration promotes cell migration, invasion, and resistance to cell deathSemantic proximity
Select a neighboring publication to make it the new centre.