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Article

Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling.

Disease models & mechanisms - 30 Apr 2020

Harsh Sneh, Fu Yulong, Kenney Eric, Han Zhe, Eleftherianos Ioannis

Abstract excerpt

To gain a comprehensive view of the changes in host gene expression underlying Zika virus (ZIKV) pathogenesis, we performed whole-genome RNA sequencing (RNA-seq) of ZIKV-infected Drosophila adult flies. RNA-seq analysis revealed that ZIKV infection alters several and diverse biological processes, including stress, locomotion, lipid metabolism, imaginal disc morphogenesis and regulation of JAK/STAT signaling. To...

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PMID: 32152180
DOI: 10.1242/dmm.040816
PMCID: PMC7197722

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