Article

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

2020-06-04

Abstract excerpt

There is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4 + T cell, and CD8 + T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE). Additionally, such vaccines can be rapidly manuf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54f8daba-72cd-575f-b31c-8200af420ecf
DOI: 10.1101/2020.06.04.135004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2DOI 10.1101/2020.06.04.135004Read

Landscape and selection of vaccine epitopes in SARS-CoV-2Semantic proximity Read

Identification of promising SARS-CoV-2 CD8+ and CD4+ T cell epitopes by immunoinformatics approach for a multi-epitope-based vaccine designSemantic proximity Read

Design of T cell epitope-based vaccine candidate for SARS-CoV-2 targeting nucleocapsid and spike protein escape variantsSemantic proximity Read

Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale ImmunitySemantic proximity Read

T cell-mediated protection against lethal SARS-CoV-2 challenge by a synthetic long peptide vaccine targeting conserved CD4+ and CD8+ T cell epitopesSemantic proximity Read

Identification of Highly Conserved SARS-CoV-2 Antigenic Epitopes with Wide Coverage Using Reverse Vaccinology ApproachSemantic proximity Read

Robust computational design and evaluation of peptide vaccines for cellular immunity with application to SARS-CoV-2Semantic proximity Read

Excavating SARS‐coronavirus 2 genome for epitope‐based subunit vaccine synthesis using immunoinformatics approachSemantic proximity Read

The multi-epitope vaccine prediction to combat Pandemic SARS-CoV-2, an immunoinformatic approachSemantic proximity Read

Multi-Epitope Vaccine Design Using an Immunoinformatic Approach for SARS-CoV-2Semantic proximity Read

A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2Semantic proximity Read

Multi-epitope Based Peptide Vaccine Design Using Three Structural Proteins (S, E, and M) of SARS-CoV-2: An <i>In Silico</i> ApproachSemantic proximity Read