Back to search

Article

Drug Resistance without a cost? Common and uncommon routes to fosfomycin resistance in Uropathogenic <i>Escherichia coli</i>

2023-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Fosfomycin kills bacteria by blocking the binding of phosphoenolpyruvate (PEP) to the bacterial enzyme MurA and halting peptidoglycan synthesis. While its use has increased with the emergence of antibiotic resistance, the mechanisms leading to fosfomycin resistance remain relatively unexplored. In uropathogenic Escherichia coli (UPEC) that accounts for >75% of urinary tract infections (UTIs), f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
544ac4b9-23b5-5f46-9e0c-3754b592d33e
DOI
10.1101/2023.06.20.545750
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Drug Resistance without a cost? Common and uncommon routes to fosfomycin resistance in Uropathogenic <i>Escherichia coli</i>DOI 10.1101/2023.06.20.545750
Prevalence, mechanisms and comparison of detection methods of fosfomycin resistance in <i>E. coli</i> from urinary tract infectionsSemantic proximity
Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli.Semantic proximity
Fosfomycin resistance mechanisms in Enterobacterales: an increasing threatSemantic proximity
<i>In vitro</i> evolution of uropathogenic <i>Escherichia coli</i> to fosfomycin resistance in a 3D cultured human bladder microtissue modelSemantic proximity
Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates.Semantic proximity
Fosfomycin susceptibility testing and resistance mechanisms in Enterobacterales in South AfricaSemantic proximity
Urinary Tract Conditions Affect Fosfomycin Activity against Escherichia coli Strains Harboring Chromosomal Mutations Involved in Fosfomycin Uptake.Semantic proximity
The Role of <i>fosA</i> in Challenges with Fosfomycin Susceptibility Testing of Multispecies <i>Klebsiella pneumoniae</i> Carbapenemase-Producing Clinical IsolatesSemantic proximity
[UhpTE350Q mutation along with the presence of fosA6/5 genes in the genome probably contributes to inherent fosfomycin resistance of Klebsiella pneumoniae].Semantic proximity
Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin ResistanceSemantic proximity
Mechanisms of fosfomycin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniaeSemantic proximity
Experiences in fosfomycin susceptibility testing and resistance mechanism determination in Escherichia coli from urinary tract infections in the UKSemantic proximity
Select a neighboring publication to make it the new centre.