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Article

Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli.

Journal of clinical microbiology - 1 Jan 2018

Lucas Aaron E, Ito Ryota, Mustapha Mustapha M, McElheny Christi L, Mettus Roberta T, Bowler Sarah L, Kantz Serena F, Pacey Marissa P, Pasculle A William, Cooper Vaughn S, Doi Yohei

Abstract excerpt

Fosfomycin maintains activity against most Escherichia coli clinical isolates, but the growth of E. coli colonies within the zone of inhibition around the fosfomycin disk is occasionally observed upon susceptibility testing. We aimed to estimate the frequency of such nonsusceptible inner colony mutants and identify the underlying resistance mechanisms. Disk diffusion testing of fosfomycin was performed on 649...

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Identifiers

PMID: 29093108
DOI: 10.1128/JCM.01368-17
PMCID: PMC5744208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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