Article

TNF-α suppresses drug resistance via NF-κB/PXR pathway in non-small cell lung cancer

2021-01-20

Abstract excerpt

<h4>Background: </h4> Reduced sensitivity to chemotherapeutic agents caused by multidrug resistance is the main obstacle in the treatment of non-small cell lung cancer (NSCLC). Activated NF-κB/PXR pathway stimulated by procytokine TNF-α is implicated in the formation of multidrug resistance phenotype. However, the underlying mechanisms are obscure, and results concluded in various tumors are conflicted. Herein, we...

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Literature Corpus work: 52df61cd-ec26-5fc8-b97f-6003989e625e
DOI: 10.21203/rs.3.rs-148624/v1

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