Article

Liddle Syndrome Caused by SCNN1B Mutation Presenting With Severe Early-Onset Hypertension and Hypokalemia in an Adolescent: A Case Report

2026-05-22

Abstract excerpt

<title>Abstract</title> <p>Background Liddle syndrome is a rare autosomal dominant form of monogenic hypertension caused by gain-of-function mutations in genes encoding the epithelial sodium channel (ENaC). The disease is characterized by early-onset hypertension, hypokalemia, metabolic alkalosis, and suppression of the renin–angiotensin–aldosterone system (RAAS). Early diagnosis is essential because targeted th...

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Literature Corpus work: 5174dbd2-31b6-5272-93d3-a880d4b7238f
DOI: 10.21203/rs.3.rs-9222506/v1

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