Article

Adeno-Associated Virus based Caveolin-1 Delivery via Different Routes for the Prevention of Cholesterol Gallstone Formation

2022-07-25

Abstract excerpt

<h4>Background: </h4> The hepatic caveolin1 (CAV1) was reduced in cholesterol gallstone disease (CGD). And mice with CAV1 deficiency were prone to develop CGD. However, it remains unknown whether the restored hepatic CAV1 expression would prevent the development of CGD. Methods C57BL/6 mice were injected with adeno-associated virus 2/8 (AAV2/8) vectors carrying CAV1 gene ( AAV2/8 CAV1) via intravenous (i.v.) or i...

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Literature Corpus work: 50ab20ed-d694-5a0f-8bcf-be4a5aad06bc
DOI: 10.21203/rs.3.rs-1852657/v1

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