Article

Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays

2025-10-13

Abstract excerpt

Metagenomics is being adopted worldwide as a laboratory developed test. We have previously reported a unified metagenomic method for the direct detection of microorganisms from respiratory samples, delivering preliminary results within six hours with >90% sensitivity for both viral and bacterial pathogens. This has now been deployed across the United Kingdom (UK) National Health Service (NHS) through the NHS Genom...

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Literature Corpus work: 50a3403f-50f5-5553-a60f-1e54548ad2d6
DOI: 10.1101/2025.10.10.25337716

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