Article

Deep Brain Stimulation Microelectrodes as a Source of Human Subcortical RNA: Validation of a Low-Input Transcriptomic Protocol

2026-07-30

Abstract excerpt

<h4>Background</h4> Understanding the molecular basis of Parkinson’s disease (PD) phenotypic heterogeneity maybe improved by in vivo access to deep brain tissue. Deep brain stimulation (DBS) surgery offers a unique opportunity: microelectrodes traversing the subthalamic nucleus (STN) carry adherent brain tissue upon withdrawal, providing a source of RNA from subcortical regions in living patients without addition...

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Literature Corpus work: 507ea32e-fa70-5cd9-8439-e54a32d0fcc9
DOI: 10.64898/2026.07.27.740887

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