Article

Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression

2021-07-05

Abstract excerpt

A major therapeutic obstacle in diabetes mellitus is the metabolic or hyperglycemic memory: the persistence of impaired organ function despite improvement of blood glucose. Therapies reversing the hyperglycemic memory and thus improving already established organ-dysfunction are lacking, but urgently needed considering the increasing prevalence of diabetes mellitus worldwide. Here we show that glucose-mediated chan...

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Literature Corpus work: 505c1ec0-31db-5af3-921a-101905d435d4
DOI: 10.1101/2021.07.05.450846

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