Article

Analysis of SFTS pathogenesis based on single-cell RNA sequencing of monocytes

2025-02-27

Abstract excerpt

<h4>Backgroud</h4> Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified tick-borne viral disease with a high mortality rate. Monocytes are known to play an important role in the pathogenesis of SFTS, but the distinct subpopulations of monocytes associated with the disease progression and their roles in inflammatory responses remain unclear. In this study, we used single-cell RNA sequencing (sc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50532a39-7bce-5952-a84b-f0ebbcf3bcf0
DOI: 10.1101/2025.02.26.640382

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of SFTS pathogenesis based on single-cell RNA sequencing of monocytesDOI 10.1101/2025.02.26.640382Read

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndromeSemantic proximity Read

Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia SyndromeSemantic proximity Read

RNA transcriptome analysis of platelets revealed altered platelet responses and the mechanism of thrombocytopenia in SFTSSemantic proximity Read

Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethalitySemantic proximity Read

Transient expansion of peripheral Lambda-expressing plasma cells represents a distinctive phenotype associated with SFTSV infection.Semantic proximity Read

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome ActivationSemantic proximity Read

Interplay of Monocytes and T Lymphocytes in COVID-19 SeveritySemantic proximity Read

A case of severe meningitis caused by SFTSV diagnosed with mNGS assistanceSemantic proximity Read

Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behçet’s diseaseSemantic proximity Read

Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146Semantic proximity Read

Severe fever with thrombocytopenia syndrome (SFTS) possibly associated with a Mustela sibirica: a case report from ChinaSemantic proximity Read

CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virusSemantic proximity Read