Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

1 Mar 2020

Abstract excerpt

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus that carries a high fatality rate of 12%-50%. In-depth understanding of the SFTSV-induced pathogenesis mechanism is critical for developing effective anti-SFTS therapeutics. Here, we report transcriptomic analysis of blood samples from SFTS patients. We observe a strong correlation between inflammatory responses and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Inflammasome and immune disorders
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32234474
DOI: 10.1016/j.celrep.2020.02.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome ActivationPMID 32234474Read ↗

Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethalitySemantic proximity Read ↗

Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia SyndromeSemantic proximity Read ↗

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic FactorsSemantic proximity Read ↗

Analysis of SFTS pathogenesis based on single-cell RNA sequencing of monocytesSemantic proximity Read ↗

RNA transcriptome analysis of platelets revealed altered platelet responses and the mechanism of thrombocytopenia in SFTSSemantic proximity Read ↗

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndromeSemantic proximity Read ↗

hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNASemantic proximity Read ↗

Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 PathwaySemantic proximity Read ↗

The SFTSV Nonstructural Proteins Induce Autophagy to Promote Viral Replication via Interaction with VimentinSemantic proximity Read ↗

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosisSemantic proximity Read ↗

Effect of Severe Fever With Thrombocytopenia Syndrome Virus Genotype on Disease Severity, Viral Load, and Cytokines in South KoreaSemantic proximity Read ↗

Pathogenesis and virulence of flavivirus infectionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.