Article

The impact of genetic modifiers on variation in germline mutation rates within and among human populations

2021-08-27

Abstract excerpt

Mutation rates and spectra differ among human populations. Here, we examine whether this variation could be explained by evolution at mutation modifiers. To this end, we consider genetic modifier sites at which mutations, “mutator alleles”, increase genome-wide mutation rates and model their evolution under purifying selection due to the additional deleterious mutations that they cause, genetic drift, and demograp...

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Literature Corpus work: 504e2e91-a284-5a9a-b5ad-7a456b7bcb8f
DOI: 10.1101/2021.08.25.457718

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