Article

Background splicing and genetic disease

2020-10-15

Abstract excerpt

We report that low level background splicing by normal genes can be used to predict the likely effect of splicing mutations upon cryptic splice site activation and exon skipping, with emphasis on the DBASS databases, BRCA1, BRCA2 and DMD. In addition we show that background RNA splice sites are also involved in pseudoexon formation, recursive splicing and aberrant splicing in cancer. We discuss how background spli...

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Identifiers and source

Literature Corpus work: 50271646-7e33-5c3e-8463-80cff4880b88
DOI: 10.21203/rs.3.rs-92665/v1

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