Article

Empirical prediction of variant-associated cryptic-donors with 87% sensitivity and 95% specificity

2021-07-28

Abstract excerpt

<title>Abstract</title> <p>Predicting which cryptic-donors may be activated by a genetic variant is notoriously difficult. Through analysis of 5,145 cryptic-donors activated by 4,811 variants (versus 86,963 decoy-donors not used; any GT or GC), we define an empirical method predicting cryptic-donor activation with 87% sensitivity and 95% specificity. Strength (according to four algorithms) and proximity to the au...

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Literature Corpus work: 342bd987-e77d-5ae6-9149-d8741ca2aee3
DOI: 10.21203/rs.3.rs-731201/v1

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