Article

What is the potential of Lumacaftor as a chemical chaperone in promoting hERG trafficking？

2024-01-30

Abstract excerpt

Lumacaftor (LUM), approved by the FDA for the treatment of cystic fibrosis(CF), has shown great therapeutic potential in protein conformational diseases. As a chemical chaperone, LUM corrects the F508del CFTR mutation and increases the expression of chloride channels on the alveolar cell membrane. After Mehta et al’s research, the selectivity of LUM has been challenged. In human induced pluripotent stem cell-deriv...

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Literature Corpus work: 4fcd1e54-af81-515a-92b9-85c4488f4308
DOI: 10.22541/au.170665535.52632337/v1

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