Back to search

Article

Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for <i>Drosophila melanogaster</i>

2025-02-08

Abstract excerpt

Single-cell genomics has revolutionized our understanding of cellular heterogeneity, but automating its analysis remains an open challenge. Cell-type annotation represents a critical bottleneck, particularly as datasets grow in size and complexity. While foundation models have shown promise in addressing this challenge, existing approaches require extensive fine-tuning for effective cell-type annotation. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4fc4ceee-df47-5ba0-a683-e59a227dda15
DOI
10.1101/2025.02.04.636468
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lemur: A Single-Cell Foundation Model with Fine-Tuning-Free Hierarchical Cell-Type Generation for <i>Drosophila melanogaster</i>DOI 10.1101/2025.02.04.636468
UniCell: Towards a Unified Solution for Cell Annotation, Nomenclature Harmonization, Atlas Construction in Single-Cell TranscriptomicsSemantic proximity
<i>deCS</i> : A Tool for Systematic Cell Type Annotations of Single-cell RNA Sequencing Data among Human TissuesSemantic proximity
A Cross-Species Generative Cell Atlas Across 1.5 Billion Years of Evolution: The TranscriptFormer Single-cell ModelSemantic proximity
Scaling cross-tissue single-cell annotation modelsSemantic proximity
Decoding cell identity with multi-scale explainable deep learningSemantic proximity
stFormer: a foundation model for spatial transcriptomicsSemantic proximity
GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation ModelSemantic proximity
Species-specific small models for cell type classification approach the performance of large single cell foundation modelsSemantic proximity
Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit flySemantic proximity
Tabular Foundation Models Are Competitive Cellular Perturbation Predictors Across Biological ScalesSemantic proximity
GeneBag: training a cell foundation model for broad-spectrum cancer diagnosis and prognosis with bulk RNA-seq dataSemantic proximity
Reference-free Cell-type Annotation for Single-cell Transcriptomics using Deep Learning with a Weighted Graph Neural NetworkSemantic proximity
Select a neighboring publication to make it the new centre.