Article

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

2023-06-30

Abstract excerpt

<h4>Background</h4> The cardiac troponin T (Tnnt2) promoter is broadly utilized for cardiac specific gene expression, particularly via adeno-associated virus (AAV)-based gene transfer. However, these vectors drive lower-level ectopic gene expression in other tissues, most notably in the liver. Whether the AAV- Tnnt2 vectors remain tissue-specific in applications sensitive to low or transient gene expression, suc...

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Literature Corpus work: 4f973784-f974-55b5-a44e-27e9fb0ab385
DOI: 10.1101/2023.06.29.546982

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