Article

Experimental and mathematical models of intracellular calcium dynamics for evaluating combined anticancer effects of Afatinib and RP4010 in esophageal cancer

2021-08-28

Abstract excerpt

Targeting dysregulated Ca 2+ signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca 2+ entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA approval to be used in targeted therapy for patients with EGFR mutation-positive cancers. While preclinical studies and c...

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Literature Corpus work: 4f57c8f8-5789-59f0-a6f4-e72e4337bae1
DOI: 10.1101/2021.08.27.457959

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