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Article

‘High vault-age’: non-coding RNA control of autophagy

1 Feb 2020

Abstract excerpt

RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the protein's function. We refer to this process as 'riboregulation'. Here, we discuss this newly uncovered vault RNA function against the background of three...

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PMID: 32070232
DOI: 10.1098/rsob.190307

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