Article

Boosting polygenic risk scores

2022-05-01

Abstract excerpt

Polygenic risk scores (PRS) evaluate the individual genetic liability to a certain trait and are expected to play an increasingly important role in the field of clinical risk stratification. Most often, PRS are estimated based on summary statistics of univariate effects derived from genome-wide association studies. To improve the predictive performance of PRS, it is desirable to fit multivariable models directly o...

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Literature Corpus work: 4d3a5ac8-1029-5315-851c-a2be1d05671a
DOI: 10.1101/2022.04.29.489836

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