Article

The lncRNA <i>FENDRR</i> fine-tunes FOXF1 protein levels through a negative feedback loop governing human embryonic lung fibroblast-to-myofibroblast transition

2026-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Precise control of transcription factor dosage is critical for lung mesenchymal development. The forkhead box transcription factor FOXF1 is a dosage-sensitive regulator of pulmonary vascularization and fibroblast differentiation, with haploinsufficiency causing the lethal neonatal disorder alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). A syntenically conserved long n...

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Literature Corpus work: 4d1f9242-f265-5c23-bd2d-093dd98f733f
DOI: 10.64898/2026.04.10.716765

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