Article

Loss of heterozygosity and absence of MAX immunostaining in a prolactinoma associated with multiple endocrine neoplasia type 5 (MEN5)

2025-11-04

Abstract excerpt

<title>Abstract</title> <p>Multiple endocrine neoplasia type 5 (MEN5) is an emerging syndrome caused by germline pathogenic variants involving the MYC Associated Factor X (MAX) gene. Affected individuals typically have pheochromocytomas, often bilateral, at a relatively early age. In MAX pheochromocytoma cohorts, pituitary adenomas are rarely reported. The role of MAX as a tumor suppressor gene in the pituitary g...

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Literature Corpus work: 4ba1bc1c-435c-5ab0-81ac-10fd9507250b
DOI: 10.21203/rs.3.rs-7760856/v2

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