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Article

Dysregulated fetal heart contraction underlies complex genetics of congenital heart disease

2023-11-10

Abstract excerpt

<title>Abstract</title> <p>The etiology of most CHD is believed to be multifactorial, potentially involving multiple concurrent genetic mutations. This study employed a large-scale ENU-based forward dominant screen in mice to explore potential novel oligogenic causes of CHD. Through screening 10,000 mice, we identified over 1,000 CHD fetuses, with ventricular septal defects and bicuspid aortic valves being the mo...

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Literature Corpus work
48cd570e-3110-5541-8a1f-0ca74e2a9b58
DOI
10.21203/rs.3.rs-3474696/v1
Open publication

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Dysregulated fetal heart contraction underlies complex genetics of congenital heart diseaseDOI 10.21203/rs.3.rs-3474696/v1
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