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Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the  IFN response through inhibitng TRIM25 oligomerization and functional activation of RIG-I/TRIM25

2024-01-29

Abstract excerpt

<title>Abstract</title> <p>Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging <italic>Alpha-coronavirus</italic>, brings huge economic loss in swine industry. Interferons (IFNs) participate in a frontline antiviral defense mechanism triggering the activation of numerous downstream antiviral genes. Here, we demonstrated that TRIM25 overexpression significantly inhibited SADS-CoV replication, whereas...

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Literature Corpus work
48a50ed9-0fdf-5c10-8252-191de7c6c2a8
DOI
10.21203/rs.3.rs-3814773/v1
Open publication

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Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibitng TRIM25 oligomerization and functional activation of RIG-I/TRIM25DOI 10.21203/rs.3.rs-3814773/v1
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