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Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomas

2025-02-07

Abstract excerpt

<title>Abstract</title> <p>Rhabdomyosarcoma (RMS) represents one of the most common soft tissue sarcoma (STS) in children and adolescents. Transforming growth factor beta 1 (TGFβ1) is a potent inhibitor of myogenic differentiation in RMS and plays a significant function in the tumour immune microenvironment. Currently, unsupervised tumor immune phenotype based on multi-omics expression profiling has been less stu...

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Literature Corpus work
898a91db-fd61-510b-ae4d-540c6e501691
DOI
10.21203/rs.3.rs-5923386/v1
Open publication

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Integrative bioinformatics analysis and experimental validation identify CHEK1 as an unfavorable prognostic biomarker related to immunosuppressive phenotypes in soft tissue sarcomasDOI 10.21203/rs.3.rs-5923386/v1
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