SCALE: Unsupervised Multi-Scale Domain Identification in Spatial Omics Data

Abstract excerpt

Single-cell spatial transcriptomics enables precise mapping of cellular states and functional domains within their native tissue environment. These functional domains often exist at multiple spatial scales, with larger domains encompassing smaller ones, reflecting the hierarchical organization of biological systems. However, the identification of these functional domain hierarchies has been hardly explored due to...

Topics

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• Algorithms
• Cluster Analysis
• Ferroptosis and cancer prognosis
• Gene expression and cancer classification
• Neural Networks, Computer
• Phenotype
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

95098b43-d61f-568c-aac7-38678a6ab1a3

DOI

10.1101/2025.05.21.653987