Article

High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Two new structures of the N-terminal domain of the main replication protein, NS1, of Human Parvovirus B19 (B19V) are presented. This domain (NS1-nuc) plays an important role in the “rolling hairpin” replication of the single-stranded B19V DNA genome, recognizing origin of replication sequences in double-stranded DNA, and cleaving ( i.e . nicking) single-stranded DNA at a nearby site known as th...

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Literature Corpus work: 4827ec28-270d-5161-917c-92475b513f14
DOI: 10.1101/2021.12.20.473600

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