Article

Impact of Temperature on Structural Changes in nsp2 and nsp3 of CHIKV: Molecular Dynamics Simulations

2022-01-17

Abstract excerpt

Authors have considered non-structural protease-2 (nsp2) and non-structural protease-3 (nsp3) of CHIKV for the investigation as they are involved in the replication of the virus and increases the infections in the human. CHIKV protease (nsp2), has a catalytic dyad (Cys 1013 /His 1083 ) that processes viral polyproteins. Further, it has also been suggested that the catalytic dyad is interchangeable to a serine (pro...

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Literature Corpus work: 47c2944c-f720-5184-bf91-1db4c88077a6
DOI: 10.21203/rs.3.rs-1252778/v1

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