Article
Collagen VI in the Musculoskeletal System.
International journal of molecular sciences - 7 Mar 2023
Di Martino Alberto, Cescon Matilde, D'Agostino Claudio, Schilardi Francesco, Sabatelli Patrizia, Merlini Luciano, Faldini Cesare
Abstract excerpt
Collagen VI exerts several functions in the tissues in which it is expressed, including mechanical roles, cytoprotective functions with the inhibition of apoptosis and oxidative damage, and the promotion of tumor growth and progression by the regulation of cell differentiation and autophagic mechanisms. Mutations in the genes encoding collagen VI main chains, COL6A1, COL6A2 and COL6A3, are responsible for a...
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