Article

An APP-centered molecular gateway integrates innate immunity and retinoic acid signaling to drive irreversible metamorphic commitment

2026-01-24

Abstract excerpt

The mechanisms by which environmental signals induce permanent developmental changes remain a fundamental biological problem. We investigated sea star metamorphosis, where microbial biofilms induce a total body plan reorganization. Using systems biology and functional assays, we identified a three-tiered signaling cascade: sensing, conversion, and execution. The immune adaptor MyD88 senses microbes, while MAPK pro...

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Literature Corpus work: 475b2ac8-5821-5e58-a479-035d1e5b878c
DOI: 10.64898/2026.01.22.700939

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