Article

Guarded LINCS/L1000 reversal of severe equine asthma recovers disease biology but no coherent non-steroidal reversal class

2026-07-13

Abstract excerpt

<title>Abstract</title> <p>Background. Severe equine asthma is a prevalent, corticosteroid-managed airway disease with no established mechanism-targeted non-steroidal therapy. We tested whether transcriptomic signature reversal against the human LINCS L1000 compound library could nominate non-steroidal repurposing hypotheses for severe equine asthma, using a disease-state anchor and an a priori, rule-based guard...

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Literature Corpus work: 46f262d1-984f-50bd-94eb-ba2a7f82e980
DOI: 10.21203/rs.3.rs-9974367/v1

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